Mario Liepe studied Music Education at the University of Hanover, followed by an artistic course at the Hanover University of Music and Drama in Clarinet with Professor Helmut Pallushek and Hans Deinzer. In a further main subject, he studied conducting with Prof. Willy Träder and Prof. Wolfram Wehnert. He then studied Economics at the Economics Academy for Teachers and completed a course of Management Training at the Trossingen Federal Academy.
He has performed widely in the area of chamber music (including the "Aperto Ensemble" and the Lower Saxony Chamber Symphony) and in the Hanover State Theatre.
From 1990-2001, he chaired the jury for the International Grotrian Steinweg Piano Competition.
He has been teaching conducting and clarinet/ classical saxophone since 1977 in various institutions: Langenhagen Music School and Ostkreis Music School Hanover.
From 1983 he was Director and a conducting and clarinet lecturer at Göttingen Music School.
From 1990 Director and clarinet lecturer at Braunschweig Music School.
From 2003 Director and conducting and clarinet lecturer at the Calenberger Land Music Schools, Hanover.
From 2004 Managing Director and clarinet lecturer at Solingen Music School, and Head of the "Centre for German-Language Choral Singing Worldwide".
Since 2008, Director and lecturer at Dr. Hoch's Conservatory - Music Academy Frankfurt am Main.
Since 1983, individual lectureships for clarinet and music management at the University of Hanover, the Technical University of Braunschweig, Hanover University of Music and Drama and the Federal Academy for Cultural Education in Wolfenbüttel.